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Medicinal plants have shown great promise in treating Alzheimer’s disease (AD), which significantly contributes to the production of pharmaceutical and cosmetic molecules with biologically efficient moieties. Plants derived bioactive compounds have been isolated from the medicinal plants and are used in brain diseases. Accountable for brain diseases. Plant extracts have undesirable effects such as acute or chronic toxicity; this could be involved in the delay or discouraging the adoption to the brain cells for proper and effective treatment. β-secretase is the primary protease in the process of producing Amyloid β (Aβ), which is an amyloid precursor protein in brain cells. This review is focused on the numerous different bioactive compounds present in medicinal plants such as Flavonoids, Phenyl propanoids, Prenylated flavones, Naphthoquinone, Resveratrol, Phlorotannins and Glycoside derivatives. Even though medicinal plants and their functional derivatives were reported to be good source of alternative medicines for long sought diseases like AD; but clinical trials on human are yet to be beyond the preliminary stages. The useful applications of these compounds, as bio-markers are also being explored, to further enrich control of Alzheimer’s.