Some Chemical Carcinogens for Leukaemia Induction and Their Animal Models

Main Article Content

Abdullahi Aliyu
Mohd Rosly Shaari
Noordin Mohamed Mustapha
Nurul Syahirah Ahmad Sayuti
Mohd Farhan Hanif Reduan
Shanmugavelu Sithambaram
Khozirah Shaari
Hazilawati Hamzah

Abstract

Animal models have been providing invaluable contributions to the better understanding of mechanisms of cancer (including leukaemias) development and effectiveness of most of the treatments. Chemical carcinogens are generally used to study the biology of cancers including leukaemias in many animal models, including rats and mice. The studies in most cases are aimed at the development and evaluation of cancer treatments and preventions. Some of the most common chemical carcinogens used in animal models for leukaemias include N-ethyl-N-nitrosourea (ENU), N-methyl-N-nitrosourea (MNU), dimethyl benz(a)anthracene (DMBA) and benzo(a)pyrene (BaP). This review provides highlights on different animal models of leukaemia induced by the chemical carcinogens mentioned earlier, at the same time discussing the contributions of these models to the leukaemia diagnosis in laboratory animal models for subsequent development of treatment.

Keywords:
Animal model, Dimethyl Benzanthracene (DMBA), Benzo (a) pyrene (BaP), Leukaemia, N-ethyl-N-nitrosourea (ENU), N-methyl-N-nitrosourea (MNU).

Article Details

How to Cite
Aliyu, A., Shaari, M., Mustapha, N., Sayuti, N. S., Reduan, M. F., Sithambaram, S., Shaari, K., & Hamzah, H. (2019). Some Chemical Carcinogens for Leukaemia Induction and Their Animal Models. Annual Research & Review in Biology, 33(1), 1-7. https://doi.org/10.9734/arrb/2019/v33i130108
Section
Review Article

References

Chang YC, Hsu JD, Lin WL, Lee YJ, Wang CJ. High incidence of acute promyelocytic leukemia specifically induced by N-nitroso- N -methylurea ( NMU ) in Sprague – Dawley rats. Arch Toxicol. 2012;86:315- 27.

DeSantis C, Siegel R, Bandi P, Jemal A. Breast cancer statistics, 2011. CA Cancer J Clin. 2011;61(6):409–18.

Boffetta P, Kaldor JM. Secondary malig-nancies following cancer chemotherapy. Acta Oncol. 1994;33(6):591–8.

Kohnken R, Porcu P, Mishra A. Overview of the use of murine models in leukemia and lymphoma research. Front Oncol [Internet]. 2017;7.
Available:http://journal.frontiersin.org/article/10.3389/fonc.2017.00022/full

Macejová D, Brtko J. Chemically induced carcinogenesis: A comparison of 1-methyl-1-nitrosourea, 7,12-dimethylbenzanthracen e,diethylnitroso-amine and azoxymethan models (minireview). Endocr Regul. 2001; 35(1):53–9.

Boyonoski AC, Spronck JC, Gallacher LM, Jacobs RM, Shah GM, Poirier GG, et al. Niacin deficiency decreases bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats. J Nutr [Internet]. 2002;132(1):108– 14.
Available:http://www.ncbi.nlm.nih.gov/pubmed/11773516

Gerson SL, Trey JE, Miller K, Berger NA. Comparison of O6-alkylguanine-DNA alkyltransferase activity based on cellular DNA content in human, rat and mouse tissues. Carcinogenesis. 1986;7(5):745– 9.

Lautier D, Lagueux J, Thibodeau J, Menard L, Poirier GG. Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol Cell Biochem [Internet]. 1993;122(2):171–93.

Available:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8232248

Le Rhun Y, Kirkland JB, Shah GM. Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase. Biochem Biophys Res Commun. 1998;245:1–10.

Zeller WJ, Schmähl D. Leukemias induced by ethylnitrosourea in Wistar rats: Incidence and chemotherapy. Leuk Res. 1979;3(4).

Law S, Maiti D, Palit A, Majumder D, Basu K, Chaudhuri S, et al. Facilitation of functional compartmentalization of bone marrow cells in leukemic mice by biological response modifiers: An immunotherapeutic approach. Immunol Lett. 2001;76(3):145–52.

Bhattacharjee B, And AKS, Maiti D. Role of G-CSF plus IL-15 on neutrophil population in peripheral blood modulating protein tyrosine kinase activity in leukemic mouse Bhaskar Bhattacharjee, Ashish Kumar Singha and Debasish Maiti. Int J Curr Res. 2015;7(4):15180–6.

Singha AK, Bhattacharjee B, Saha B, Maiti D. IL-3 and GM-CSF modulate functions of splenic macrophages in ENU induced leukemia. Cytokine [Internet]. 2017;91:89-95.
Available:http://dx.doi.org/10.1016/j.cyto.2016.12.009

da Silva Franchi CA, Bacchi MM, Padovani CR, de Camargo JL. Thymic lymphomas in Wistar rats exposed to. Cancer Sci. 2003; 94(3):4–7.

Hutheyfa AH, Hamzah H, SMR, Sabri J, Mohamed Mustapha NSS. Histopatho-logical features of peripheral T-cell lymphoma in sprague dawley rats induced with N-methyl-N-nitrosourea. Pertanika J Trop Agric Sci [Internet]. 2011;34:351– 61.
Available:http://psasir.upm.edu.my/25342/

Elghetany MT, MacCallum JM, Davey FR. The use of cytochemical procedures in the diagnosis and management of acute and chronic myeloid leukemia. Clin Lab Med. 1990;10(4).

Sugiyama CBH, T. Induction of leukaemia in rat by pulse doses. Pathology. 1965; 55:74–81.

Sugiyama T, Osaka M, Koami K, Maeda S, Ueda N. 7,12-DMBA-induced rat leukemia: A review with insights into future research. Leuk Res [Internet]. 2002;26(12):1053–68.
[Cited 2017 May 5]
Available:http://ezproxy.upm.edu.my:2055/science/article/pii/S0145212602000450

Shi Z, Dragin N, Miller ML, Stringer KF, Johansson E, Chen J, et al. Oral benzo[a]pyrene-induced cancer: Two distinct types in different target organs depend on the mouse Cyp1 genotype. Int J Cancer. 2010;127(10):2334–50.

Miller KP, Ramos KS. Impact of cellular metabolism on the biological effects of benzo[a]pyrene and related hydrocarbons. Drug Metab Rev. 2001;33(1):1–35.