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COV-19, HIV/AIDS, Flu H1N1 and many other zoonotic diseases are emergent during Anthropocene epoch due to climatic anomalies. Bacteria’s, viruses, pathogens are associated with human cause zoonoses mainly resulting from domestication. Minimum 61% of human pathogens are zoonotic comprising 75% of all emerging apocalyptic pathogens in 21st century. The scope of present study is investigating the domestication in time scale and finding the causes and consequences the virulent invasion of the present 21st century zoonotic diseases due to the climatic, biologic, socio-economic causes and the governing laws during the Anthropocene. The Holocene hominids were strong enough to adapt the harsh, frigid climate to sustain life during extreme conditions. Later the food habits, sedentary life and the changing agro-climate made then incapable to sustain with the bacterial, viral and microbial attacks for lack of immunity and adaptability by invoking domestication. The National Health Profile, India; has reported fall in rate of communicable diseases that has out broken from 61% to 33% from 1990 to 2016 resulting from health education, care and vaccines but the pandemicCOVID-19 has challenged the scenario. Demand of one health practices and stringent laws is essential to overcome the risk. Present pandemic COVID-19 has forced the globe away for sustenance of life and livelihood for want of vaccine, it is essential to practice five ‘T’ (Test, Trace, treat, train and trade) to restore the normal life.
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