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Sesame is an important oilseed crop due to its different types of commercial application. The produced oil from sesame uses for food and beauty care product preparation due to its high nutritive value. However, the yield of sesame is comparatively low than other oilseed crops. Nitrogen and Boron are essential nutrients for plant development and growth. So, the combined application of nitrogen and boron can increase the yield of sesame. From these perspectives, an experiment was carried out to study the effect of nitrogen and boron application on yield contributing characters and yield of sesame. The experiment consisted of four Nitrogen doses (N0: 0 kg N/ha (control), N1: 50 kg N/ha, N2: 60 kg N/ha, N3: 70 kg N/ha) and three Boron doses (B0: 0 kg B/ha (control), B1: 2 kg B/ha, B2: 3 kg B/ha). It was laid out in two factors Randomized Complete Block Design (RCBD) with three replications. Result demonstrated that combination of 60 kg N/ha and 3.0 kg B/ha were acceptable for getting better yield and maximum economic return from the studied parameters.