Possible Impact of Select Trace Mineral Deficiency in HIV Seropositive Pregnant Women with/without Malaria Co-infection in NAUTH, Nnewi, Nigeria
Annual Research & Review in Biology,
Page 53-62
DOI:
10.9734/arrb/2020/v35i530225
Abstract
Aims: To evaluate the impact of HIV and malaria on serum Zinc (zn), Selenium (se) and Magnesium (mg) in HIV seropositive pregnant women in Nnewi, Nigeria.
Study Design: This is a case-control study.
Place and Duration of Study: Prevention of Mother to Child transmission (PMTCT) of HIV Clinic of Nnamdi Azikiwe University Teaching Hospital, Nnewi, (NAUTH), Nigeria, between December, 2017 and April, 2018.
Methodology: We included 122 consented female participants; 32 HIV seropositive pregnant women with malaria parasitaemia, 30 HIV seropositive pregnant women without malaria parasitaemia, 30 Malaria infected pregnant women, 30 pregnant women without HIV or malaria parasitaemia, aged between 18 and 42 years. Screening for HIV antibodies and malaria parasite was double screened using National algorithm, rapid detection technique (RDT) and Giemsa staining microscopy technique respectively. Micronutrient levels were determined using atomic absorption spectrophotometry (AAS).
Results: When the mean zn, sel and mg levels were compared between the test and control groups, significant decreases in serum zn (37.34 ± 6.7, 36.70 ± 4.39), sel (29.93 ± 6.02, 28.00 ± 5.04) and mg (2.41 ± 0.46, 2.33 ± 0.14) were observed in HIV seropositive pregnant participants with/without malaria co-infection when compared with their corresponding controls Zn (45.1 ± 7.83, 50.36 ± 8.73); Sel (31.46 ± 6.19, 31.96 ± 6.81); Mg (2.62 ± 0.30) and (P < .05 respectively). Body mass index (BMI) was significantly decreased while diastolic blood pressure (DBP) and systolic blood pressure (SBP) were significantly increased in HIV seropositive pregnant women with malaria compared with their seronegative counterparts (P < .05 respectively).
Conclusion: The significant loss in BMI with derangement in serum zn, sel and mg levels in HIV seropositive pregnant women with/without malaria co-infection indicates high degree of malnutrition while the increased blood pressure suggests high blood pressure which might predispose the pregnant mothers to pre-eclampsia if not properly managed. Adequate micronutrient supplementation and effective anti malaria agent is strictly advocated in the routine management of HIV infected mothers during pregnancy to reduce the severity of the co-infection and adverse pregnancy complications especially in areas of malaria endemic transmissions.
Keywords:
- HIV/malaria
- co-infection
- trace minerals
- pregnancy
How to Cite
References
DOI: 10.2147/RRTM.S154501
Ezechi O, Petterson KO, Byamugisha J. HIV/AIDS, Tuberculosis, and Malaria in Pregnancy. J Pregnancy. 2012;140826.
DOI: 10.1155/2012/140826.
Sanyaolu AO, Fagbenro-Beyioku AF, Oyibo WA, Badaru OS, Onyeabor OS, Nnaemeka CI. Malaria and HIV co-infection and their effect on haemoglobin levels from three health-care institutions in Lagos, southwest Nigeria. Afr Health Sci. 2013; 13:295–300.
DOI: 10.4314/ahs.v13i2.14
Ayisi JG, van Eijk AM, Newman RD. Maternal malaria and perinatal HIV transmission, Western Kenya, Emerging Infect Dis. 2004;10:643–652.
Cosby AS, Kosuke K, Roland K, Wafaie WF. November the role of selenium in HIV infection. Nutri Rev. 2010;68:671–81.
Nandi S, Irlam J, Visser ME, Rollins NN. Micronutrient Supplementation in Pregnant Women with HIV Infection. Review. Cochrane Database Syst Rev. 2012;3: CD009755. DOI: 10.1002/14651858.CD009755
Murray CK, Gasser RA, Magill AJ, Miller RS. Update on rapid diagnostic testing for malaria. Clin Microbiol Rev. 2008;21:97-110.
WHO. Malaria parasite counting. Malaria standard operating procedure. 2016; MMSOP. 09.
Unger HW, Ashorn P, Cates JE.. Undernutrition and malaria in pregnancy – a dangerous dyad?. BioMed Central Med. 2016;142.
Lindsay KL, Buss C, Wadhwa PD, Entringer S. The interplay between maternal nutrition and stress during pregnancy: Issues and Considerations. Ann Nutr Metab. 2017;70:191‐200.
Pathak P, Kapil U, Dwivedi SN, Singh R. Serum zinc levels amongst pregnant women in a rural block of Haryana State, India. Asian Pac. J Clin Nutr. 2008;17:276 – 9.
Besecker BY, Exline MC, Hollyfield J, Phillips G, Disilvestro RA. A comparison of zinc metabolism, inflammation and disease severity in critically ill infected and non-infected adults early after intensive care unit admission. Am J Clin Nutri. 2011;93: 1356–64.
Iribhogbe OI, Agbaje EO, Oreagba IA, Aina OO, Ota AD. Therapeutic potential of selected micronutrients in malaria: An in vivo study in Plasmodium berghei infected mice. Biol Med. 2012;4:193–210.
Vanessa Matinez Manfio VM, Tasca KI, Gatto M, Loureiro da Silva V, Golim MA, De Souza LR "HIV-Infected Pregnant Women: A Microbial Translocation and Inflammatory Status Discussion." AIDS Res Hum Retro. 2019;35:217–218
Lindsay KL, Buss C, Wadhwa PD, Entringer S. The Interplay between Maternal Nutrition and Stress during Pregnancy: Issues and Considerations. Ann Nutr Metab 70:191‐200.
Roland K, Ferdinand M, Said A, Gernard IM, Julia LF, Donna S, et al. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and child outcomes, Am J Clin Nutr. 2008;87:1802–8.
Ogbodo SO, Okaka ANC, Nwagha U, Ejezie FE, Okafor CS. Oxidative stress in symptomatic malaria parasitemic pregnant women from Malaria Endemic Area of Nigeria. Am J Med Mcd Sci. 2014;4:1 68-74.
Bella SD, Grilli E, Cataldo MA, Petrosillo N. Selenium deficiency and HIV infection. Infect Dis Rep. 2010;2:e18.
DOI: 10.4081/idr.2010.e18
Ogbodo SO, Okaka NC, Nwagha UI. Anti-infective antioxidant minerals levels in uncomplicated pregnancy in some rural communities of South East Nigeria. J Med Neutrino Nutraceut. 2013;9:52–7.
Gernand AD, Schulze KJ, Stewart CP, West KP, Christian P. Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nature Reviews Endocrinology. 2016;12(5): 274‐289.
Jahnen-Dechent W, Ketteler M. Magnesium basics. Clin kidney J. 2012;5: 13-4.
Eduardo Villamor, Michele L. Dreyfuss, Ana Baylín, Gernard Msamanga, Wafaie W. Fawzi. Weight loss during pregnancy Is associated with adverse pregnancy outcomes among HIV-1 Infected Women, The Journal of Nutrition. 2004;134(60): 1424–1431
Mohammad YY, Yasir PK, Zulfiqar AB. Maternal mineral and vitamin supplementation in pregnancy. Expert Rev Obstet Gynecol. 2010;5:241-56.
Elaheh Z, Amal T. Effect of magnesium supplement on pregnancy outcomes: A randomized control trial. Adv Biomed Res. 2017;6:109.
DOI: 10.4103/2277-9175.213879
Villamor E, Msamanga G, Spiegelman D, Peterson KE, Antelman G, Fawzi WW. Pattern and predictors of weight gain during pregnancy among HIV-1 infected women from Tanzania and HIV-related loss of body mass J Acquir Immune Def Syndr. 2003;32:560–9.
Galinsky R, Polglase GR, Hooper SB, Black MJ, Moss TJM. The Consequences of Chorioamnionitis: Preterm birth and effects on development. J Pregnancy. 2013;412831.
DOI: 10.1155/2013/412831
Coloma AG, Alvarez AM, Roca-Cusachs CA, et al. Prevalence of arterial hypertension and lipid profile in HIV patients. Medicina Clinica. 2008;131:681-4.
Sattler FR, Qian D, Louie S. Elevated blood pressure in subjects with therapy on blood pressure in HIV-infected patients. A prospective study in a cohort of naive patients. AIDS. 2001;15:15.
DOI: 10.1097/00002030-200110190-00013
Ukibe NR, Onyenekwe CC, Anojulu AA, Onwubuya E, Kalu AO, UKIBE SN. Impact of Plasmodium falciparum malaria infection on serum cortisol, adrenocorticotropic hormone, pregnancy associated plasma protein-A and alpha-fetoprotein in pregnant women at Nnewi. Int J Biol Chem Sci 2019;13:1222-1230.
DOI:https://dx.doi.org/10.4314/ijbcs.v13i3.1
Malasundera RC, Larbalestier N, Smith JH, de Ruiter A, McG Thom SA, Hughes AD Preeclampsia, antiretroviral therapy, and immune reconstitution. Lancet. 2002; 360:1152–4i.
Ndao A, Dumont N, Fievet S, Doucoure A, Gaye, Lehesran JY. Placental malarial infection as a risk factor for hypertensive disorders during pregnancy in Africa: A case-control study in an Urban Area of Senegal. West Afr Am J Epidemiol. 2009; 170:847–53.
Onyenekwe CC, Meludu SC, Dioka CE, Salimonu LS. Prevalence of asymptomatic malaria parasitaemia amongst pregnant women. Indian J Malarial. 2002;39:60-5.
Dorman E, Shulman C. Malaria in pregnancy. Mini-symposium: Infections in pregnancy. Curr trends Obstet Gynecol. 10:183–9.
Jauniaux E, Poston L, Burton GJ. Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution. Hum Repro Update. 2006;12:747–55.
Baillie JK, Bates MG, Thompson AA, Waring WS, Partridge RW, Schnopp MF. Endogenous urate production augments plasma antioxidant capacity in healthy lowland subjects exposed to high altitude. Chest. 2007;131:1473–8.
Osuji FN, Onyenekwe CC, Ifeanyichukwu M, Ahaneku JE, Ezeani M, Ezeugwunne IP. Antioxidant activity in HIV and malaria co-infected subjects in Anambra State, southeastern Nigeria. Asian Pacific J Trop Med. 2012; 841-7.
Clark IA, Budd AC, Alleva LM. Cowden WB. Human malarial disease: A consequence of inflammatory cytokine release. Malar J 2006;5:85.
DOI: 10.1186/1475-2875-5-85
French N, Nakiyingi J, Lugada E, Watera C, Whitworth JA., Gilks CF. Increasing rates of malarial fever with deteriorating immune status in HIV-1-infected Ugandan adults. AIDS. 2001;15:899–906.
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