Whey Protein Supplement: An Exclusive Food or Need of the Hour: Review
Annual Research & Review in Biology,
Background: Protein is an essential portion of food that exerts beneficial effects on body composition and metabolism. However, protein-rich foods are costly and scarcely available in developing countries, and protein deficiency is a significant public health concern. In this situation, searching for additional dietary protein sources is of utmost importance due to decreasing resources because of the growing global population. The current literature review is about whey protein as it is the cheapest, readily available protein source.
Methods: Milk is formed of two proteins, casein and whey. Whey is different from the casein in milk and is formed as a by-product of the cheese-making process. Whey (the liquid left after milk curdling) was deemed a waste by the dairy industry for decades. However, it is the cheapest protein source for the poor growing populations in developing countries. Whey protein is a complete protein as it contains all nine essential amino acids. It is low in lactose content.
Conclusion: Human body cannot make essential amino acids, so it is necessary to get enough of them from the diet. Due to the availability of carbohydrates, fat, immunoglobulins, lactose, and minerals, including essential amino acids in whey protein, it is necessary for human energy. There are many benefits related to whey protein consumption, such as muscle building and loss of fat. New possible therapeutic properties of whey protein have to be investigated further for the full utility to humans.
- Whey protein
- cheapest protein
How to Cite
Marshall K. Therapeutic applications of whey protein. Alt Med Rev. 2004;9(2):136-156.
Lollo PC, Farfan AJ, de Carvalho-Silva LB. Physiological and physical effects of different milk protein supplements in elite soccer players. J Hum Kinet. 2011;30:49-57.
Josse AR, Phillips SM. Impact of milk consumption and resistance training on body composition of female athletes. Med Sport Sci. 2012;59:94-103.
Athira S, Mann B, Sharma R, Kumar R. Ameliorative potential of whey protein hydrolysate against paracetamol-induced oxidative stress. J Dairy Sci. 2013; 96:1431–1437. DOI:10.3168/jds.2012-6080.[PubMed] [Cross Ref]
Xu R, Liu N, Xu X, Kong B.Antioxidative effects of whey protein on peroxide induced cytotoxicity. J Dairy Sci.2011; 94(8):3739-3746.
Blome RM, Drackley JK, McKeith FK, Hutjens MF, McCoy GC. Growth, nutrient utilization, and body composition of dairy calves fed milk replacers containing different amounts of protein. J Anim Sci.2003;81(6):1641-1655.
Mortensen LS, Hartvigsen ML, Brader LJ, Astrup A, Schrezenmeir J, et al. Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: Comparison of whey, casein, gluten and cod protein. Am J ClinNutr.2009;90(1):41-48.
Saito T. Antihypertensive peptides derived from bovine casein and whey proteins. AdvExp Med Biol. 2008;606:295-317.
Coker RH, Miller S, Schutzler S, Deutz N, Wolfe RR. Whey protein and essential amino acids promote the reduction of adipose tissue and increased muscle protein synthesis during caloric restriction-induced weight loss in elderly, obese individuals. Nutr J.2012;11:105.
Burd NA, West DW, Moore DR, Atherton PJ, Staples AW, et al. Enhanced amino acid sensitivity of myofibrillar protein synthesis persists for up to 24 h after resistance exercise in young men. J Nutr.2011;141(4):568-573.
De Bandt JP, Cynober L. Therapeutic use of branched-chain amino acids in burn, trauma, and sepsis. J Nutr.2006;136(30): 8S-13S.
Luigi F, Nicole EC, Apelo A, Sebastian I, Joshua CN, et al. Decreased consumption of branched-chain amino acids improves metabolic health. Cell Rep.2016;16(2): 520-530.
Grimble RF, Grimble GK.Immunonutrition: role of sulfur amino acids, related amino acids, and polyamines. Nutrition.1998; 14(7-8):605- 610.
Gupta A, Chaphalkar SR. Quantitative estimation of lactoferrin and leukocytes contents in bovine, sheep, and goat samples. J Adv Food Sci Tech.2016;3(1): 21-24.
Gupta A, Chaphalkar SR. Flow cytometric estimation of lactoferrin content in bovine milk samples. J Adv Food Sci Tech.2016; 3(1):36-40.
Bell SJ. Whey protein concentrates with and without immunoglobulins: a review. J Med Food.2000;3(1):1-13.
Steele WF, Morrisons M.Antistreptococcal activity of lactoperoxidase. J Bacteriol.1969;97(2):635-639.
Björck L, Rosen CG, Marshall V, Reiter B. Antibacterial activity of lactoperoxidase system in milk against pseudomonas and other gram-negative bacteria. ApplMicrobiol.1975;30(2):199-204.
Shin K, Hayasawa H, Lönnerdal B. Purification and quantification of lactoperoxidase in human milk with use of immunoadsorbents with antibodies against recombinant human lactoperoxidase. Am J ClinNutr. 2001;73(5):984-989.
Kelleher SL, Chatterton D, Nielsen K, Lönnerdal B.Glycomacropeptide and alpha-lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys. Am J ClinNutr.2003;77(5):126-128.
Ren J. Alpha-lactalbumin possesses a distinct zinc-binding site. J Biol Chem.1993;268(26):19292-19298.
Abrahão V. Nourishing the dysfunctional gut and whey protein. CurrOpinClinNutrMetab Care. 2012;15:480–484. DOI:10.1097/MCO.0b013e328356b71e. [PubMed] [Cross Ref]
Gerez CL, Font de Valdez G, Gigante ML, Grosso CRF. Whey protein coating bead improves the survival of the probiotic Lactobacillus rhamnosus CRL 1505 to low pH.LettApplMicrobiol. 2012;54:552– 556. DOI:10.1111/j.1472-765X.2012.03247.x. [PubMed] [Cross Ref]
Walsh H, Cheng J, Guo M. Effects of carbonation on probiotic survivability, physicochemical, and sensory properties of milk-based symbiotic beverages. J Food Sci. 2014;79:M604–M613. DOI: 10.1111/1750-3841.12381. [PubMed] [Cross Ref]
Hébrard G, Hoffart V, Beyssac E, et al. Coated whey protein/alginate microparticles as oral controlled delivery systems for probiotic yeast. J Microencapsul. 2010;27:292–302. DOI:10.3109/02652040903134529. [PubMed] [Cross Ref]
Morton JP, Kayani AC, McArdle A, Drust B. The exercise-induced stress response of skeletal muscle, with specific emphasis on humans. Sports Med. 2009;39:643–662. DOI: 10.2165/00007256-200939080-00003. [PubMed] [Cross Ref]
Freidenreich DJ, Volek JS. Immune responses to resistance exercise. Exerc. Immunol Rev. 2012;18:8–41. [PubMed]
Martin V, Ratel S, Siracusa J, et al. Whey proteins are more efficient than casein in the recovery of muscle functional properties following a casting induced muscle atrophy. PLoS One. 2013;8: e75408. DOI: 10.1371/journal.pone.0075408. [PMC free article] [PubMed] [Cross Ref]
Churchward-Venne TA, Breen L, Di Donato DM, et al. Leucine supplementation of a low-protein mixed macronutrient beverage enhances myofibrillar protein synthesis in young men: a double-blind, randomized trial. Am J ClinNutr. 2014;99:276–286. DOI:10.3945/ajcn.113.068775. [PubMed][Cross Ref]
Lollo PCB, Amaya-Farfan J, Faria IC, et al. Hydrolyzed whey protein reduces muscle damage markers in brazilian elite soccer players compared with whey protein and maltodextrin. A twelve-week in-championship intervention. Int Dairy J. 2014;34:19–24. DOI: 10.1016/j.idairyj.2013.07.001.[Cross Ref]
Volek JS, Volk BM, Gómez AL, et al. Whey protein supplementation during resistance training augments lean body mass. J Am CollNutr. 2013;32:122–135. DOI:10.1080/07315724.2013.793580.[PubMed] [Cross Ref]
Pérez-Cano FJ, Marín-Gallén S, Castell M, et al. Bovine whey protein concentrate supplementation modulates maturation of immune system in suckling rats. Br J Nutr. 2007;2:98(Suppl 1):S80–S84.[PubMed]
Alexander DD, Schmitt DF, Tran NL, et al. Partially hydrolyzed 100 % whey protein infant formula and atopic dermatitis risk reduction: a systematic review of the literature. Nutr Rev. 2010;68:232–245. DOI: 10.1111/j.1753-4887.2010.00281.x. [PubMed] [Cross Ref]
Prussick R, Prussick L, Gutman J. Psoriasis improvement in patients using glutathione-enhancing, nondenatured whey protein isolate: A pilot study. J ClinAesthetDermatol. 2013;6:23–26.[PMC free article] [PubMed]
Essick EE, Sam F. Oxidative stress and autophagy in cardiac disease, neurological disorders, aging, and cancer. Oxidative Med Cell Longev. 2010;3:168–177. DOI: 10.4161/oxim.3.3.12106.[PMC free article] [PubMed] [Cross Ref]
Piccolomini AF, Iskandar MM, Lands LC, Kubow S. High hydrostatic pressure pre-treatment of whey proteins enhances whey protein hydrolysate inhibition of oxidative stress and IL-8 secretion in intestinal epithelial cells. Food Nutr Res; 2012. [PMC free article] [PubMed]
Lands LC, Iskandar M, Beaudoin N, et al. Dietary supplementation with pressurized whey in patients with cystic fibrosis. J Med Food. 2010;13:77–82. DOI:10.1089/jmf.2008.0326. [PubMed][Cross Ref]
De Moura CS, Lollo PCB, Morato PN, et al. Whey protein hydrolysate enhances the exercise-induced heat shock protein (HSP70) response in rats. Food Chem. 2013;136:1350,–1357. DOI:10.1016/j.foodchem.2012.09.070. [PubMed] [Cross Ref]
Moura CS, Lollo PCB, Morato PN, et al. Whey protein hydrolysate enhances HSP90 but does not alter HSP60 and HSP25 in skeletal muscle of rats. PLoS One. 2014;9:e83437. DOI: 10.1371/journal.pone.0083437. [PMC free article] [PubMed] [Cross Ref]
Kishta OA, Iskandar M, Dauletbaev N, et al. Pressurized whey protein can limit bacterial burden and protein oxidation in Pseudomonas aeruginosa lung infection. Nutrition. 2013;29:918–924. DOI:10.1016/j.nut.2012.11.009. [PubMed] [Cross Ref]
Attaallah W, Yilmaz AM, Erdoğan N, et al. Whey protein versus whey protein hydrolyzate for the protection of azoxymethane and dextran sodium sulfate induced colonic tumors in rats. PatholOncol Res. 2012;18:817–822. DOI: 10.1007/s12253-012-9509-9 [PubMed] [Cross Ref]
Castro GA, Maria DA, Bouhallab S, Sgarbieri VC. In vitro impact of a whey protein isolate (WPI) and collagen hydrolysates (CHs) on B16F10 melanoma cells proliferation. J Dermatol Sci. 2009;56:51–57. DOI:10.1016/j.jdermsci.2009.06.016. [PubMed] [Cross Ref]
Takata T, Tanaka F, Yamada T, et al. Clinical significance of caspase-3 expression in pathologic-stage I, nonsmall-cell lung cancer. Int J Cancer. 2001; 96(Suppl):54–60. DOI: 10.1002/ijc.10347.[PubMed] [Cross Ref]
Dillon EL, Basra G, Horstman AM, et al. Cancer cachexia and anabolic interventions: a case report. J CachexSarcopenia Muscle. 2012;3:253–263. DOI: 10.1007/s13539-012-0066-6. [PMC free article][PubMed] [Cross Ref]
Ballard KD, Kupchak BR, Volk BM, et al. Acute effects of ingestion of a novel whey-derived extract on vascular endothelial function in overweight, middle-aged men and women. Br J Nutr. 2013;109:882–893. DOI:10.1017/S0007114512002061. [PubMed] [Cross Ref]
SheikholeslamiVatani D, AhmadiKaniGolzar F. Changes in antioxidant status and cardiovascular risk factors of overweight young men after six weeks supplementation of whey protein isolate and resistance training. Appetite. 2012; 59:673–678. DOI:10.1016/j.appet.2012.08.005. [PubMed][Cross Ref]
Casqueiro J, Casqueiro J, Alves C.Infections in patients with diabetes mellitus: a review of pathogenesis. Indian J EndocrinolMetab. 2012;16(Suppl 1):S27–S36. [PMC free article] [PubMed]
Sousa GTD, Lira FS, Rosa JC, et al. Dietary whey protein lessens several risk factors for metabolic diseases: a review. Lipids Health Dis. 2012;11:67. DOI: 10.1186/1476-511X-11-67. [PMC free article][PubMed] [Cross Ref]
Jain SK. L-cysteine supplementation as an adjuvant therapy for type-2 diabetes. Can J PhysiolPharmacol. 2012;90:1061–1064. DOI: 10.1139/y2012-087. [PubMed] [Cross Ref]
Badr G, Badr BM, Mahmoud MH, et al. Treatment of diabetic mice with undenatured whey protein accelerates the wound healing process by enhancing the expression of MIP-1α, MIP-2, KC, CX3CL1 and TGF-β in wounded tissue. BMC Immunol. 2012;13:32. DOI: 10.1186/1471-2172-13-32.[PMC free article] [PubMed] [Cross Ref]
Salehi A, Gunnerud U, Muhammed SJ, et al. The insulinogenic effect of whey protein is partially mediated by a direct effect of amino acids and GIP on β-cells. NutrMetab (Lond). 2012; 9:48. DOI: 10.1186/1743-7075-9-48. [PMC free article] [PubMed] [Cross Ref]
Mortensen LS, Holmer-Jensen J, Hartvigsen ML, et al. Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes. Eur J ClinNutr. 2012;66:799–805. DOI:10.1038/ejcn.2012.48. [PubMed] [Cross Ref]
Toedebusch RG, Childs TE, Hamilton SR, et al. Postprandial leucine and insulin responses and toxicological effects of a novel whey protein hydrolysate-based supplement in rats. J IntSoc Sports Nutr. 2012;9:24. DOI: 10.1186/1550-2783-9-24. [PMC free article] [PubMed] [Cross Ref]
Freudenberg A, Petzke KJ, Klaus S.Dietary L-leucine and L-alanine supplementation have similar acute effects in the prevention of high-fat diet-induced obesity. Amino Acids. 2013;44:519–528. DOI:10.1007/s00726-012-1363-2. [PubMed] [Cross Ref]
Tahavorgar A, Vafa M, Shidfar F, et al. Whey protein preloads are more beneficial than soy protein preloads in regulating appetite, calorie intake, anthropometry, and body composition of overweight and obese men. Nutr Res; 2014 [PubMed] Available:https://www.rxlist.com/whey_protein/supplements.htm; Available:https://www.drugs.com/mca/whey-protein
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