Severe Oligospermia Treatment with Testicular Sperm Using “ICSI”
Annual Research & Review in Biology,
Page 37-44
DOI:
10.9734/arrb/2022/v37i630514
Abstract
Introduction: Assisted reproductive technology has been developed significantly throughout the past few years, particularly diagnosing and treating male infertility. Many studies have been performed showing that Intracytoplasmic Sperm Injection (ICSI) is a successful method to attain clinical pregnancy and live birth through impaired spermatozoa characteristics or low sperm count, such as severe oligospermia. Severe oligospermia indicates low sperm count, which in some cases leads to azoospermia. Severe oligospermia can be caused by several factors such as genetics or medication. In search of efficient treatment for couples with Severe oligospermia, numerous retrospective and prospective researches have reported high pregnancy and live birth rates through testicular sperm for men with severe oligospermia and cryptozoospermia with or without high sperm DNA damage. The research showed that the use of testicular sperm in combination with ICSI yielded a high pregnancy rate and live births over another source of sperm, such as ejaculated sperms. Moreover, the use of ICSI in severe oligospermia has shown successful fertilization and pregnancy.
Methods: In search for effective treatment for couples with severe male factor, a number of small retrospective and prospective studies have reported high pregnancy and live birth rates using testicular sperm for men with necrozoospermia, cryptozoospermia and oligozoospermia with or without elevated sperm DNA damage. Although the data suggest that there may be some benefit in performing testicular sperm retrieval (TSR)-ICSI in select groups of non-azoospermic infertile men, there are potential risks involved with TSR. Clinicians should balance these risks prior to the recommendation of TSR-ICSI on the result of a semen analysis or sperm DNA test alone. Careful evaluation and management of male factor infertility is important. The use of TSR-ICSI in the absence of specific sperm DNA defects is still experimental.
Discussion: In 1992 and subsequently, several reports indicated that ICSI was a successful technique to achieve clinical pregnancy and live birth using spermatozoa with severely impaired characteristics. The initial optimism over the ability of ICSI to overcome significant sperm abnormalities was later tempered by the findings of more recent publications suggesting that some sperm deficits may not be as effectively treated with ICSI.
Conclusion: Severe oligospermia indicates low sperm count, which can lead to male infertility; severe oligospermia which can be overcome through ICSI. Genetic factors like microdeletions of the Y chromosome (Yq) can cause severe oligospermia or chemotherapy molecules, affecting the sperm count directly.
Keywords:
- Severe oligospermia
- Medication and cancer treatment influence on oligozoospermia
- ICSI for men with sever oligozoospermia
- testicular sperm
- sperm retrieval
- ICSI
- male infertility
- sperm DNA
How to Cite
References
de Vries F, Bruin M, Lobatto D, Dekkers O, Schoones J, van Furth W, Pereira A, Karavitaki N, Biermasz N, Zamanipoor Najafabadi A. Opioids and Their Endocrine Effects: A Systematic Review and Meta-analysis. The Journal of Clinical Endocrinology & Metabolism. 2019;105(4): 1020-1029.
Delessard M, Saulnier J, Rives A, Dumont, L, Rondanino C, Rives N. Exposure to Chemotherapy during Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility. International Journal of Molecular Sciences. 2020;21(4):1454.
Dohle G. Genetic risk factors in infertile men with severe oligozoospermia and azoospermia. Human Reproduction. 2002; 17(1):13-16.
Esteves S, Miyaoka R, Agarwal A. Sperm retrieval techniques for assisted reproduction. International braz J Urol. 2011;37(5):570-583.
Esteves S, Sánchez-Martín F, Sánchez-Martín P, Schneider D, Gosálvez J. Comparison of reproductive outcome in oligozoospermic men with high sperm DNA fragmentation undergoing intracytoplasmic sperm injection with ejaculated and testicular sperm. Fertility and Sterility. 2015;104(6):1398-1405.
Esteves S, Roque M, Garrido N. Use of testicular sperm for intracytoplasmic sperm injection in men with high sperm DNA fragmentation: a SWOT analysis. Asian Journal of Andrology. 2018;20(1):1.
Hashimoto H, Ishikawa T, Goto S, Kokeguchi S, Fujisawa M, Shiotani M. The Effects of Severity of Oligozoospermia on Intracytoplasmic Sperm Injection (ICSI) Cycle Outcome. Systems Biology in Reproductive Medicine. 2010;56(1):91-95.
HM M. Reproductive Outcomes in Patients with Severe Oligospermia Undergoing Intracytoplasmic Sperm Injection using Testicular Versus Ejaculated Spermatozoa. Investigations in Gynecology Research & Womens Health (IGRWH). 2019;3(1).
Krausz C, Riera-Escamilla A. Genetics of male infertility. Nature Reviews Urology. 2018;15(6):369-384.
Leaver RMale infertility: An overview of causes and treatment options. British Journal of Nursing. 2016;25(18):S35-S40.
McLachlan R. Approach to the Patient with Oligozoospermia. The Journal of Clinical Endocrinology & Metabolism. 2013;98(3): 873-880.
Mehta A, Bolyakov A, Schlegel P, Paduch D. Higher pregnancy rates using testicular sperm in men with severe oligospermia. Fertility and Sterility. 2015;104(6):1382-1387.
Mehta R, Makwana S, Ranga G, Srinivasan R, Virk S. Prevalences of oligozoospermia and azoospermia in male partners of infertile couples from different parts of India. Asian Journal of Andrology. 2006;8(1):89-93.
Mukhtar H, Shaman A, Mirghani H, Almasalmah A. The Outcome of Assisted Reproductive Techniques among Couples with Male Factors at Prince Khalid Bin Sultan Fertility Centre, Kingdom of Saudi Arabia. Open Access Macedonian Journal of Medical Sciences. 2017;5(5):603-607.
Muratori M. Origin and biological significance of DNA fragmentation in human spermatozoa. Frontiers in Bioscience. 2009;11(1):1491.
Reynolds-Wright J, Anderson R. Male contraception: where are we going and where have we been. BMJ Sexual & Reproductive Health. 2019;45(4):236-242.
Turhan N, Pekel A, Ayrim A, Bayrak Ö. ICSI outcome in severely oligoasthenozoospermic patients and its relationship to prewash progressive sperm motility. Turk J Med Sci; 2011.
Zorrilla M, Yatsenko A. The Genetics of Infertility: Current Status of the Field. Current Genetic Medicine Reports. 2013;1(4):247-260.
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