Genomic Study of TCF7L2 Gene Mutation on Insulin Secretion for Type 2 DM Patients: A Review
Annual Research & Review in Biology,
Aim: This paper aims to establish whether a correlation between TCF7L2 gene mutation on insulin secretion for Type 2 DM Patients.
Background: Diabetes type 2 is the most common metabolic disorder worldwide. Beta cell dysfunction reduces insulin secretion and increases the glucose level in the blood and insulin resistance that raises the glucose production in the liver and decreases the glucose uptake to muscle, liver, and adipose tissue causing hyperglycemia (T2DM). TCF7L2 (transcription factor 7–like 2) works as a nuclear Receptor for CTNNB1(B catenin) that mediated the WNT signaling pathway (a group of signal transduction pathways made of proteins that pass signals from outside a cell through cell surface receptors to the inside of the cell) and any variation will cause the development of T2DM.
Methods: GenBank in NCBI database was used to extract the DNA sequence and mRNA sequence of the TCF7L2 gene (an accession number of the gene, number of amino acids, exons, and length of nucleotides). FASTA format was also useful to retrieve the nucleotide sequence and get the function of the protein. BLAST was used to compare the protein product of the TCF7L2gene between humans and gorillas, and pygmy chimpanzees (Pan paniscus).
Results: The accession number is NC_000010.11, the number of amino acids in the protein product is 602, the number of exons found is 20 and the gene is in chromosome 10. Finally, many organisms have the same gene as dogs, cows, mice, rats, zebrafish, and frogs.
Conclusion: There is a strong association between TCF7L2 (transcription factor 7–like 2) alleles (rs7903146) T alleles and T2DM. It was found that there is a high frequency of diabetic type two patients having TCF7L2 (transcription factor 7–like 2) alleles (rs7903146) with a high frequency of the T allele.
- TCF7L2 (transcription factor 7–like 2)
- T2DM (type 2 diabetes mellitus)
How to Cite
DOI: 10.2991/jegh.k.191028.001, PMID 32175717.
Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, et al. Pathophysiology of type 2 diabetes mellitus. Int J Mol Sci. 2020;21(17):6275.
DOI: 10.3390/ijms21176275, PMID 32872570.
Kolb H, Martin S. Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes. BMC Med. 2017; 15(1):131.
DOI: 10.1186/s12916-017-0901-x, PMID 28720102.
Wu Y, Ding Y, Tanaka Y, Zhang W. Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. Int J Med Sci. 2014; 11(11):1185-200.
DOI: 10.7150/ijms.10001, PMID 25249787.
Bosque‐Plata L, Hernández‐Cortés EP, Gragnoli C. The broad pathogenetic role of tcf7l2in human diseases beyond type 2 diabetes. J Cell Physiol. 2021;237(1):301-12.
Del Bosque-Plata L, Martínez-Martínez E, Espinoza-Camacho MÁ, Gragnoli C. The role of tcf7l2in type 2 diabetes. Diabetes. 2021;70(6):1220-8.
Gupta V, Khadgawat R, Saraswathy KN, Sachdeva MP, Kalla AK. Emergence of TCF7L2 as a most promising gene in predisposition of diabetes type II. Int J Hum Genet. 2008;8(1-2):199-215.
Villareal DT, Robertson H, Bell GI, Patterson BW, Tran H, Wice B, et al. TCF7L2 variant RS7903146 affects the risk of type 2 diabetes by Modulating incretin Action. Diabetes. 2010;59(2): 479-85.
DOI: 10.2337/db09-1169, PMID 19934000.
Daniele G, Gaggini M, Comassi M, Bianchi C, Basta G, Dardano A, et al. Glucose metabolism in high-risk subjects for type 2 diabetes carrying the RS7903146tcf7l2gene variant. J Clin Endocrinol Metab. 2015;100(8):E1160-7.
DOI: 10.1210/jc.2015-1172, PMID 26046964.
Bahaaeldin AM, Seif AA, Hamed AI, Kabiel WAY. Transcription factor 7-like-2 (tcf7l2) RS7903146 (C/T) polymorphism in patients with type 2 diabetes mellitus. Dubai Diabetes Endocrinol J. 2020; 26(3):112-8.
Mustafa S, Younus D. Association of TCF7L2 RS7903146 polymorphism with the risk of type 2 diabetes mellitus (T2DM) among Kurdish population in Erbil Province, Iraq. Indian J Clin Biochem. 2021;36(3):312-8.
DOI: 10.1007/s12291-020-00904-7, PMID 34220006.
Barra GB, Dutra LA, Watanabe SC, Costa PG, Cruz PS, Azevedo MF et al. Association of the RS7903146 single nucleotide polymorphism at the transcription factor 7-like 2 (TCF7L2) locus with type 2 diabetes in Brazilian subjects. Arq Bras Endocrinol Metabol. 2012;56(8):479-84.
DOI: 10.1590/s0004-27302012000800003, PMID 23295285.
Elhourch S, Arrouchi H, Mekkaoui N, Allou Y, Ghrifi F, Allam L, et al. Significant association of polymorphisms in the TCF7L2 gene with a higher risk of type 2 diabetes in a Moroccan population. J Pers Med. 2021;11(6):461.
DOI: 10.3390/jpm11060461, PMID 34073870.
Hameed T, Khan Z, Imran M, Ali S, Albegali AA, Ullah MI, et al. Associations of transcription factor 7-like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan. Afr Health Sci. 2021;21(1):15-22.
DOI: 10.4314/ahs.v21i1.4, PMID 34394276.
Hosseinpour-Niazi S, Mirmiran P, Hosseini S, Hadaegh F, Ainy E, Daneshpour MS, et al. Effect of TCF7L2 on the relationship between lifestyle factors and glycemic parameters: A systematic review. Nutr J. 2022;21(1):59.
DOI: 10.1186/s12937-022-00813-w, PMID 36155628.
Foroughmand AM, Shafidelpour S, Zakerkish M, Borujeni MP. Association between the UBE2Z RS46522 and TCF7L2 RS7903146 polymorphisms with type 2 diabetes in south western Iran. Afr Health Sci. 2019;19(3):2484-90.
DOI: 10.4314/ahs.v19i3.24, PMID 32127821.
Amoli MM, Amiri P, Tavakkoly-Bazzaz J, Charmchi E, Hafeziyeh J, Keramatipour M, et al. Replication of TCF7L2 RS7903146 association with type 2 diabetes in an Iranian population. Genet Mol Biol. 2010;33(3):449-51.
DOI:10.1590/S1415-47572010005000056, PMID 21637413.
Abstract View: 359 times
PDF Download: 54 times