Annual Research & Review in Biology

Pimple, acne, sunburn mark and pigmentation are issues that affected every individual at least once during life time. Consumers have begun to search for a product that can cure the skin issue and grant them with a good and healthy skin such as anti-acne cream. Nevertheless, most of the anti-acne creams available in the market contain lots of chemicals that may have some kinds of side effects to the consumers. The present study was conducted to formulate and evaluate the anti-acne cream containing Syzygium samarangense fruits extract. The antibacterial activity of the extract and cream in different concentrations were investigated using two gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) two gram-negative bacteria (Escherichia coli and Salmonella enterica) through disc diffusion method. The antibacterial potential of the extract was studied with four different concentrations (5, 10 and 25 mg/ml). The extract showed significant antibacterial activity against all the tested organisms. This activity was well maintained when the extract was incorporated into the cream formulation with the concentrations of 10, 25, 50 and 100 mg/ml. The formulated cream was also stable after two months. This formulated creams can be successfully used for skin infections which including acne vulgaris, after the confirmation of clinical and toxicity studies in future.