Adiponectin: Obesity and Development of Different Diseases
Q. F. B. Amado Israel de la Cruz Galindo
Faculty of Chemistry, Autonomus University of the State of México, Paseo Colón S/N, Residencial Colón, 50120, Toluca de Lerdo, México.
Jonnathan Guadalupe Santillán Benítez *
Faculty of Chemistry, Autonomus University of the State of México, Paseo Colón S/N, Residencial Colón, 50120, Toluca de Lerdo, México.
Enrique Morales Avila
Faculty of Chemistry, Autonomus University of the State of México, Paseo Colón S/N, Residencial Colón, 50120, Toluca de Lerdo, México.
*Author to whom correspondence should be addressed.
Abstract
Adiponectin is an adipokine abundantly expressed in adipose tissue, which has been well characterized, demonstrating its beneficial effect on human health, circulates in the bloodstream in various isoforms, playing different roles in the balance of energy homeostasis. Adiponectin is an insulin sensitizing hormone that exerts its action through AdipoR1, AdipoR2 and T-cadherin receptors. AdipoR1 is abundantly expressed in muscle, whereas AdipoR2 is expressed predominantly in the liver. Adiponectin is inversely proportional to obesity, diabetes and other states of insulin resistance; this review presents current findings regarding regulation, production and biological effects. Adiponectin acts by activating AMPk (AMP-activated protein kinase) and thus the enzymatic modulation so that the signaling pathways play an important role in the regulation, in addition to the above it has been demonstrated that the deregulation in the biogenesis and function of the miRNAs contributes to the appearance and development of diverse diseases.
Keywords: Adiponectin, adipokine, obesity, AdipoR1, AdipoR2