AQP2 Genes and Nephrogenic Diabetes Insipidus: A Review
Monica Soni
Mewar University, Gangrar, Chittorgarh, Rajasthan, India.
Arvind Pareek *
Vardhman Mahaveer Open University, Kota, Rajasthan, India.
*Author to whom correspondence should be addressed.
Abstract
Nephrogenic Diabetes insipidus (NDI) is an issue coming about because of lacking against diuretic hormone (ADH) activity and is described by the entry of extensive measures of exceptionally dilute urine. This problem must be separated from other polyuric states, for example, essential polydipsia, osmotic diuresis and diabetes mellitus. Diabetes insipidus is a condition when a person is passing urine with excess of water, this condition arise due to improper re-absorption of water during urine formation. Aquaporins (AQPs) play a important role in absorption of water. AQP2 is quite dominant than other isoforms.
This article provides nutshell information about Diabetes Insipidus and role of Aquaporin-2 gene in its physiology.
Keywords: AQP2, Nephrogenic diabetes insipidus, Vesopressin