Annual Research & Review in Biology

Vitamin B12 Deficiency Presenting as Pyrexia of Unknown Origin: A Case Report

Surendra Khosya *

Rajasthan University of Health Sciences, Jaipur, India and Maharaja Agrasen Institute of Medical Education and Research, Agroha, Haryana, India.

Sunil Kumar Gothwal

Rajasthan University of Health Sciences, Jaipur, India and Maharaja Agrasen Institute of Medical Education and Research, Agroha, Haryana, India.

Nilesh Gharpure

Rajasthan University of Health Sciences, Jaipur, India and Maharaja Agrasen Institute of Medical Education and Research, Agroha, Haryana, India.

*Author to whom correspondence should be addressed.

---

Abstract

Vitamin B₁₂ deficiency is an uncommon cause of fever. Here we describe a case of a 16-year-old male who presented with pyrexia of unknown origin from one and half month subsequently on investigation patient diagnosed to nutritional megaloblastic anemia secondary to severe vitamin B₁₂ deficiency after exclusion of other infective, neoplastic or inflammatory causes. Megaloblastic anemia (vitamin B12, folate deficiency) is a reversible cause of pyrexia that should be considered in any patient who presents with pyrexia from long time and pancytopenia.

Keywords: Pyrexia of unknown origin, megaloblastic anemia, pancytopenia

---

---