Annual Research & Review in Biology

Cancer is the second leading cause of death worldwide. Although great advancements have been made in the treatment and control of cancer progression, significant deficiencies and room for improvement remain. A number of undesired side effects such as vomiting, hair loss, immunosupression, free radical formation etc. occur during chemotherapy. Free radicals are the cause of oxidative stress, which may causes injury to cells, gene mutation, and may lead to cancer. Oxidative stress can also causes cancer, by the interaction with intracellular signal transduction and transcription factors, directly or indirectly. An antioxidant is any substance that delays, prevents or removes oxidative damage to a target molecule. This can be achieved by the entrance of substances such as phytotherapeutic molecules, oxidation inhibitors, vitamins, minerals, in the body from different natural sources. These compounds neutralize the free radicals and prevent from excessive production of harmful elements in the body. Phytotherapeutic molecules are the secondary metabolites which hold the promise to design new drugs in drug development process for treatment of lot of diseases such as cancer. This review is attempt to screen and explore the role of phytotherapeutic molecules and oxidative inhibitors as novel and secures approach of anticancer and chemo-preventive agents. There are lots of natural therapies available in traditional medicine system such as phytotherapy, immunotherapy etc. to prevent and sometimes cure the cancer. The herbs, spices, vegetables & fruits are the rich source of phytotherapeutic molecules and antioxidants which are strongly active against carcinogenesis.