Bioactive Compounds of the Salivary Glands from Aedes aegypti with Anti-Hemostatic Action
Bruno Marcel Silva de Melo
Pharmacy School, Federal University of Pará / UFPA, Belém, PA, Brazil.
Norma Luciene Lima da Silva
Pharmacy School, Federal University of Pará / UFPA, Belém, PA, Brazil.
Rafaelli de Souza Gomes
Graduate Program in Pharmaceutical Sciences, Pharmacy School, Federal University of Pará / UFPA, Belém, PA, Brazil.
Kely Campos Navegantes
Graduate Program in Pharmaceutical Sciences, Pharmacy School, Federal University of Pará / UFPA, Belém, PA, Brazil.
Ana Lígia de Brito Oliveira
Pharmacy School, Federal University of Pará / UFPA, Belém, PA, Brazil.
Lorena Almeida
Pharmacy School, Federal University of Pará / UFPA, Belém, PA, Brazil.
Carolina Heitmann Mares Azevedo
Pharmacy School, Federal University of Pará / UFPA, Belém, PA, Brazil and Graduate Program in Pharmaceutical Sciences, Pharmacy School, Federal University of Pará / UFPA, Belém, PA, Brazil.
Marta Chagas Monteiro *
Pharmacy School, Federal University of Pará / UFPA, Belém, PA, Brazil and Graduate Program in Pharmaceutical Sciences, Pharmacy School, Federal University of Pará / UFPA, Belém, PA, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Blood-sucking arthropods evolved a salivary cocktail of anti-hemostatic, platelet antiaggregant and vasodilators components that neutralize the effects of hemostasis and allow a successful blood supply occurs. In salivary glands from Aedes aegypti was found several components with anti-hemostatic action that inhibit the platelet aggregation and coagulation. These anticoagulants can prevent clot formation during the ingestion and digestion of blood meals by the Ae. aegypti insect. Thus, this review focused in Ae. aegypti saliva components that have anticlotting action and that has potential sources of novel pharmacologically active molecules, as potential therapeutic of new cardiovascular and anti-thrombotic drugs.
Keywords: Aedes aegypti, salivary bioactive compounds, blood clotting, anti-hemostatic.