Study of the Effects of Sorghum bicolor (Poaceae) on Duodenal Motility in Rabbits
KAMBOU Sansan Philippe *
Laboratory of Medical Biochemistry, Medical Sciences Training and Research Unit, Félix Houphouët Boigny University, Abidjan, Côte d’Ivoire.
Angbo Kousso Marie Angéline
Laboratory of Medical Biochemistry, Medical Sciences Training and Research Unit, Félix Houphouët Boigny University, Abidjan, Côte d’Ivoire.
Kolia Kouamé Innocent
Pasteur Institute of Côte d’Ivoire, Côte d’Ivoire.
Bahi Calixte
Biology and Health Laboratory, Biosciences Department, UFHB, Abidjan, Côte d’Ivoire.
Bedou Kouassi Denis
Biology and Health Laboratory, Biosciences Department, UFHB, Abidjan, Côte d’Ivoire.
Cissé-Camara Massara
Laboratory of Medical Biochemistry, Medical Sciences Training and Research Unit, Félix Houphouët Boigny University, Abidjan, Côte d’Ivoire.
*Author to whom correspondence should be addressed.
Abstract
In this study,carried out to evaluate the gastrointestinal tolerance of the aqueous extract of Sorghum bicolor leaf sheath used in the treatment of anemia in Côte d'Ivoire. An aqueous extract of whole Sorghum bicolor seeds was prepared using cold maceration method. Segments of rabbit duodenum were used for the experiment. Aqueous extracts of Sorghum bicolor induce a dose-dependent reduction in duodenal muscle contractions. Aqueous extracts of Sorghum bicolor inhibit acetylcholine-induced tonic concentrations by 94% at a concentration of 1000 µg/mL. The aqueous extract of Sorghum. bicolor had intestinal muscle relaxant properties. These results support its pharmacological potential as an antispasmodic agent.
Keywords: Sorghum bicolor, duodenum, rabbit, duodenal motility, traditional medicine.