Association of Helicobacter pylori IgG Antibody with Microvascular Complications in Type II Diabetic Patients
Jamshid Vafaeimanesh
Internist, Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Mohammad Bagherzadeh
Internist, Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
Vahid Damanpak
General physician, Qom University of Medical Sciences, Qom, Iran.
Mahmoud Parham *
Endocrinologist, Clinical Research Development Center, Qom University of Medical Sciences, Qom,
*Author to whom correspondence should be addressed.
Abstract
Aims: The aim of this study was to investigate the association between HP infection and microvascular complications of type two diabetes mellitus (T2DM).
Study Design: Cross-sectional study.
Place and Duration of Study: Shahid Beheshti Hospital of Qom, Iran, between March 2012 and March 2013.
Methodology: In this cross-sectional study 211 T2DM patients have been examined. Subjects were divided into two groups (HP+ and HP-) based on HP infection (diagnosed with IgG serology), and the association between these groups and microvascular complications of T2DM including nephropathy (based on protein excretion in 24-hour urine collection), retinopathy (based on examination by an ophthalmologist) and neuropathy (diapason and monofilament examination) has been evaluated.
Results: Of the 211 subjects studied, 125 (59.24%) were HP+. The mean diabetes duration was not significantly different in both groups. A significant association was found between HP infection and diabetic neuropathy (p=0.04), but there was no correlation between HP infection and diabetic nephropathy and retinopathy (p=0.2 and p=0.43, respectively). Conclusion: Infection with H. pylori increases the risk of diabetic neuropathy and is considered as a possible risk factor diabetic neuropathy.
Keywords: Diabetes mellitus, diabetes complications, Helicobacter pylori