A Formula of Bacterial Pathogenicity (Theoretical Review)
Yurii V. Ezepchuk *
The Gamaleya Institute for Epidemiology and Microbiology, Moscow, Russia and National Jewish Medical and Research Center, Denver, Colorado, U.S.A.
*Author to whom correspondence should be addressed.
Abstract
Four fundamental biological functions are responsible for bacterial pathogenicity in a multi-cellular host organism: the adhesive function, the function of invasion and penetration into the cell, the function of evasion of host defense, and the damage function. The action of the first three of them (adhesion, invasion and evasion) is directed to towards establishing an ecological niche in Multi-cellular host, while the aim of the damaging function is destruction of this environment.
Keywords: Bacterial pathogenicity, biological function, adhesions, invasions, toxins; bio-molecules, “pathogenicity islands, infectious diseases, prokaryotic and eukaryotic organisms