Helicobacter Pylori Infection Might be a Potential Protective Factor against Classic Multiple Sclerosis in Guilan, Iran
Masoumeh Ahmadi Jalali Moghadam
Cellular and Molecular Research Center, Faculty of Medicin, Guilan University of Medical Sciences, Rasht, Iran.
Hamidreza Honarmand *
Department of Microbiology, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Hamidreza Hatamian
Department of Neurology, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Ali Roudbary
Department of Neurology, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran.
*Author to whom correspondence should be addressed.
Abstract
Aims: The current study was aimed to investigate any relation between H. pylori seropositivity to IgA and IgG with MS.
Study Design: Cross sectional study
Place and Duration of Study: The present study was performed in the Department of Microbiology, Guilan University of Medical Sciences between Aprill 2012 and Aprill 2013
Methodology: H. pylori infection was certified by ELISA in study group (n=46) and control group (n=46) using commercial assays (Anti H.pylori IgG and IgA,). Data were analyzed by using two statistical tests (Chi square and Spearman's rho correlation).
Results: Seropositivity rate of H. pylori IgG was 33.3% in study group but 67.4% in control group and seropositivity rate of H. pylori IgA was 11.9% in study group but 30.2% in control group. The frequency of IgG seropositivity was significantly more in control group than study group (P Chi-Square =0.002 , Correlation Coefficient=-0.341 and P Spearman's rho correlation (Sig. 2-tailed)=0.001) ) and the frequency of IgA seropositivity was also significantly more in control group than study group (P Chi-Square =0.039 and Correlation Coefficient=-0.224, P Spearman's rho correlation (Sig. 2-tailed)= 0.039 ).
Conclusion: H. pylori seropositivity to IgG and IgA showed significant inverse association with affection to MS. Findings of this study suggests that H. pylori infection is not a causative factor but might be a protective factor against development of classic MS.
Keywords: H. pylori infection, immunological effect, multiple Sclerosis