Biological Activity of Chrysanthemum coronarium L. Extracts
Abd El Raheim M. Donia *
Pharmacognosy Department, College of Pharmacy, Salman Bin Abdulaziz University, Al-Kharj, Saudi Arabia and Department of Medicinal and Aromatic Plants, Desert Research Center, Cairo, Egypt.
*Author to whom correspondence should be addressed.
Abstract
Aim: The current research was designed to evaluate the biological and antioxidant activities of Chrysanthemum coronarium.
Methodology: Two main experiments were designed to evaluate the biological activity of ethanolic extract Chrysanthemum coronarium first one concerned with hepatoprotective activity at concentrations of 200 and 400mg/kg, the second experiment was established to study the effect of the same doses on male fertility.
Results: Our results revealed that; total extract of C. coronarium and their four fractions (diethyl ether, chloroform, ethyl acetate and n-butanol) showed antioxidant activity, in which the highest activity achieved with ethyl acetate fraction. In biological evaluation C. coronarium at dose of 400mg/kg showed hepatoprotective activity, also it showed significant improvement of the relative weight of reproductive organs, sperm count, sperm motility, total sperm abnormality, testosterone and LH.
Conclusion: The results suggest that C. coronarium has a significant hepatoprotective activity and improve fertility at 400mg/kg.
Keywords: Chrysanthemum coronarium, antioxidant, hepatoprotective activity, sex hormones.