Oral Adverse Reaction to Cefuroxime Axetil
V. Vucicevic Boras *
Department of Oral medicine, School of Dentistry, University of Zagreb and Clinical Hospital Center Rebro, Kispaticeva 12, Zagreb, Croatia.
V. Brailo
Department of Oral medicine, School of Dentistry, University of Zagreb and Clinical Hospital Center Rebro, Kispaticeva 12, Zagreb, Croatia.
D. Vidovic Juras
Department of Oral medicine, School of Dentistry, University of Zagreb and Clinical Hospital Center Rebro, Kispaticeva 12, Zagreb, Croatia.
S. Ljubojevic Hadzavdic
Clinic for Dermatology, Clinical Hospital Center Rebro, Kispaticeva 12, Zagreb, Croatia.
D. Gabric Panduric
Department of Oral Surgery, School of Dentistry, University of Zagreb, Croatia.
*Author to whom correspondence should be addressed.
Abstract
A 62 year old female patient was referred to the Department of oral medicine due to the severe oral reaction two days after she started to use cefuroxime axetil. Buccal and sublingual mucosa was very inflamed and covered with thick pseudomembranes. Patient was otherwise healthy and did not take any medication. She was advised to stop the suspected drug intake immediately and was given intramuscular methylprednisolone injection (40mg, i.e. 1mg/kg) as well as chlorhexetidine mouthwash with local anaesthetic (Xylocaine) to be used at home three times a day. After seven days the lesions healed completely. Two months after the adverse drug side effect, allergic tests were performed. In vitro tests (indirect degranulation of basophile granulocytes and blast transformation of lymphocytes) as well asepicutaneous test were negative to cefuroxime axetil.
Keywords: Cefuroxime axetil, oral adverse reaction.