The Antibacterial Activity of 2-aminoindanbiguanide Chloride and Acetate Salts against Resistant Gram-negative Bacilli
Hayriye Genç *
Chemistry Department, Faculty of Arts and Sciences, Sakarya University, Sakarya, Turkey.
OÄŸuz Karabay
Clinical Microbiology Department, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
*Author to whom correspondence should be addressed.
Abstract
Antiseptics and disinfectants are important substances for medical care. However, the needs for new antiseptics have increased in the last few years, due to multi-drug resistant pathogens. In this study we aimed to evaluate, the efficacy of 2-aminoindanbiguanide chloride (2-AIB.HCI) and 2-aminoindanbiguanideacetate (2-AIB.HOAc) salts that were synthesized against multi-drug resistant Gram-negative bacilli (MDR-GNB) (Acinetobacter spp, Escherichia coli and Klebsiella pneumoniae). According to our resultsat70 mg/mL concentrations of 2-AIB.HCI and 2-AIB.HOAc salts have been confirmed to be effective against hospital infection causing MDR-GNB. It was shown that 2-AIB.HCI and 2-AIB.HOAc salts have antibacterial efficacy against MDR-GNB.
Keywords: Multi-drugresistantbacteria, disinfectant, disinfection, 2-aminoindanbiguanide salts.