Effect of Selenium-yeast on Cognitive Performance on Pregnant Dams Exposed to Noise Stress
Okwute Michael Ochayi *
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Baze University, Abuja, Nigeria and Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, University of Nigeria, Nsukka (Enugu Campus), Enugu State, Nigeria.
Bond Anyaehie
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, University of Nigeria, Nsukka (Enugu Campus), Enugu State, Nigeria.
Eghosa Iyare
Department of Physiology, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, University of Nigeria, Nsukka (Enugu Campus), Enugu State, Nigeria.
DanAzumi Umar Haruna
Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine and Health Sciences, Baze University, Abuja, Nigeria.
Andrew E. Ivang
Department of Clinical Biology-Huye-Campus, Clinical Anatomy Unit, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda.
*Author to whom correspondence should be addressed.
Abstract
A total of twelve pregnant Wistar rats were used, and randomly divided into three groups (n=4). Group A (negative control), not exposed to noise stress), group B (1mL/kg of distilled water + 4h /15 days noise stress), group C (0.04 mg/kg) of selenium-yeast + 4 h/15 days noise stress). On day 18 and 19 of gestation cognitive tests were conducted using Y-maze and Novel Object Recognition Test. A significant increase (P ˂ 0.05) was observed in the percentage alternation and discrimination index in group A compared with group B. However, the percentage alternation and DI were significantly (P ˂ 0.05) decreased in group C compared with group B. In conclusion, noise stress induces cognitive deficit, this deficit can be mitigated with the administration of selenium-yeast.
Keywords: Noise stress, pregnant dams, cognition, selenium-yeast